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مقالات فارسیISIکنفرانسهاژورنالها

Comparing Length and Telomere Expression at Oral Precancerous and Cancerous Stages

محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 19، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 14

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لینک ثابت به این مقاله:
https://civilica.com/doc/1974012

شناسه ملی سند علمی:

JR_IJP-19-2_002

تاریخ نمایه سازی: 19 اردیبهشت 1403

چکیده مقاله:

Background & Objective: Telomeres consist of repetitive G-rich nucleotides located at the end of each chromosome, acting as protein binding sites. The aim of this study was to examine the differences in telomere length in blood, saliva, and tissue samples at various stages of oral precancerous and cancerous lesions.Methods: Samples of blood, tissue, and saliva were collected from patients with oral precancerous and cancerous lesions. DNA extraction was performed. Then, a TRAP assay was conducted to assess and compare the telomere length and telomerase expression.Results: The levels of telomerase activity (TA) in the DNA samples ranged from ۰.۱۹ to ۶.۹۱ (۲.۰۵+۱.۳۷) among oral squamous cell carcinoma (OSCC) patients and from ۰.۱۷ to ۴.۵ (۰.۲۸+۴.۲۵) among precancerous patients. A significant difference was observed in TA levels between OSCC and precancerous samples (t=۳.۹۶۹۱, P= ۰.۰۰۰۰).Conclusion: Assessing the telomerase activity is crucial for studying the behavior of carcinoma in the clinical setting. The augmented telomerase expression and the length of telomere contribute to OSCC progression. Hence, this study adds a diagnostic tool that can serve as a biomarker for the early detection and prognosis of OSCC.

کلیدواژه ها:

Carcinoma ، Biomarkers ، DNA ، Prognosis ، Telomere

نویسندگان

Fahad Samadi

Department of Oral Pathology and Microbiology, King George Medical University, Lucknow, India

Shaista Suhail

Department of Oral Pathology and Microbiology, King George Medical University, Lucknow, India

Manjari Sonam

Department of Oral Pathology and Microbiology, Sardar Patel PG Institute of Dental and Medical Sciences, Lucknow, India

Mohd Ahmad

Department of Biochemistry, KGMU, Lucknow, India

Vijay Kumar

Department of Surgical Oncology, King George Medical University, Lucknow, India

Shaleen Chandra

Department of Oral Pathology and Microbiology, King George Medical University, Lucknow, India

Shadab Mohammad

Department of Oral Maxillofacial Surgery, King George Medical University, Lucknow, India

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