Vijaykumar S. More - Department of Chemistry, Kai. Rasika Mahavidyalaya Deoni, Dist. Latur, ۴۱۳۵۱۹, (M.S.), India
Sharad P. Panchgalle - Department of Chemistry, K. M. C. College Khopoli, Dist. Raigad, ۴۱۰۲۰۳, (M.S.), India
Ranjit A. Gayake - Department of Chemistry, Swami Vivekanand Sr. College Mantha, Dist. Jalna, ۴۳۱۴۰۱(MS), India
Vasant B. Jagrut - Department of Chemistry, Swami Vivekanand Sr. College Mantha, Dist. Jalna, ۴۳۱۴۰۱(MS), India
Manisha M. Kodape - Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, ۴۴۴۶۰۲ (MS), India
Deekshaputra R. Birhade - Shri Vyankatesh Arts, Commerce and Science College Deulgaon Raja, Dist. Buldana, ۴۴۳۲۰۴ (MS), India
Mahendra N. Lokhande - Department of Chemistry, Aavvaiyar Government College for Women Karaikal, Pondicherry, ۶۰۹۶۰۲, India

Naphthalene chalcones (۳a-i) with excellent yields were achieved through the use of aromatic ketones, ۱-naphthaldehyde, and aqueous NaOH in the synthesis process. The synthesized chalcones were bio-evaluated as potential tubulin polymerization inhibitors for the treatment of breast cancer. The antiproliferative potential of each synthesized compound against the MCF-۷ cell line was assessed. The majority of the compounds showed strong antiproliferative properties. With an IC۵۰ value of ۲۲۲.۷۲ µg/mL, compound ۳f exhibited the most antiproliferative activity among them, surpassing that of ۵FU (IC۵۰, ۵۱.۴۷ µg/mL).

Naphthalene, chalcone Breast cancer Antitumor activity MCF, ۷ cell line